The Hepworth Lab

Q. Ma, H.S. Liu, H.-J. Li, W.P. Bai, Q.-F. Gao, S.-D. Wu, X.-X. Yin, Q.-Q. Chen, Y.-Q. Shi, T.-G. Gao, A.-K. Bao, H.-J. Yin, L. Li, O. Rowland, S.R. Hepworth, S. Luan, and S.-M. Wang. (2024). Genomic analysis reveals phylogeny of Zygophyllales and mechanism for water retention of a succulent xerophyte. Plant Physiology 195, 617-639.

V. Pautot*, J. Crick, and S.R. Hepworth* (2024). Abscission zones: Cellular interface for the programmed separation of organs. Annals of Botany (revision requested).  *co-corresponding authors. Impact: invited review.

Y. Wang, S. Li, C. Bergin, B. Oyetoran, S. Chatfield, R. Datla, D. Xiang, Y.-C. Liu, L. Li, Z. Wang, J. O'Neill, C. Blackman, N. Manes, M. Smith, R. Subramaniam, and S.R. Hepworth (2023). BLADE-ON-PETIOLE 1 and 2 with clade I TGACG-motif binding transcription factors contribute to pattern-triggered immunity in Arabidopsis thaliana. New Phytologist (revision requested).  

W.-P. Bai, H.-J. Li, S.R. Hepworth, H.-S. Liu, L.-B. Liu, G.-N. Wang, Q. Ma, A.-K. Bao, and S.-M. Wang (2023). Physiological and transcriptomic analyses reveal theromotolerance mechanisms in xerophyte Zygophyllum xanthoxylum. BMC Plant Biology 23, 7.  

S. Li, B. Devi, G. Allam, A. Bhullar, J. Murmu, E. Li, and S.R. Hepworth. (2023). Regulation of secondary growth by poplar BLADE-ON-PETIOLE genes in Arabidopsis. Frontiers in Plant Science 14, 1244583.  

M.G. Miltenburg, C. Bonner, S.R. Hepworth, M. Huang, C. Ramptisch, and R. Subramaniam. (2022). Proximity-dependent biotinylation identifies a suite of candidate effector proteins from Fusarium graminearum. Plant Journal 112, 369-382.  

J. Crick, L. Corrigan, K. Belcram, M. Khan, J. Dawson, B. Adroher, S. Li, S.R. Hepworth*, and V. Pautot*. (2022). Floral organ abscission in Arabidopsis requires the combined activities of three TALE homeodomain transcription factors. Journal of Experimental Botany 73, 6150-6169. * co-corresponding authors. Impact: this paper featured as Editor's Choice. 

M. Li, C. Liu, S.R. Hepworth, C. Ma, H. Li, J. Li, S.-M. Wang, and H. Yin (2021). SAUR15 interaction with BRI1 activates plasma membrane H+-ATPase to promote organ development of Arabidopsis. Plant Physiology 189, 2454-2466.

N. Manes, E. Brauer, S.R. Hepworth, and R. Subramaniam (2021). MAMP and DAMP signalling contributes resistance to Fusarium graminearum in Arabidopsis. Journal of Experimental Botany 72, 6628-6639.

H.-J. Yin, M. Li, M. Lv, S.R. Hepworth, D. Li, C. Ma, J. Li, and S.-M. Wang (2020) SAUR15 promotes lateral and adventitious root development via activating H+-ATPases and auxin biosynthesis. Plant Physiology 184, 837-851. Impact: journal issued a news and views commentary on this article

R.S. Kalinger, I.P. Pulsifer, S.R. Hepworth, and O. Rowland. (2020) Fatty acyl synthetases and thioesterases in plant lipid metabolism: diverse functions and biotechnological applications. Lipids 55, 435-455.  Impact: invited review in special tribute issue. 

W.-W. Chai, W.-Y. Wang, Q. Ma, H.-J. Yin, S.R. Hepworth, and S.-M. Wang. (2019) Comparative transcriptome analysis reveals unique genetic adaptations conferring salt tolerance in a xerohalophyte. Functional Plant Biology 46, 670-683.

J.L. Parsons, S.L. Martin, T. James, G. Golenia, E.A. Boudko*, and S.R. Hepworth*. (2019) Polyploidization for the genetic improvement of Cannabis sativa. Frontiers in Plant Science 10, 476.  *co-corresponding authors. Impact: top 96% based on views, journal metrics report

Y. Wang, B.C. Salasini, M. Khan, B. Devi, M. Bush, R. Subramaniam, and S.R. Hepworth. (2019) Clade I TGA bZIP transcription factors mediate BLADE-ON-PETIOLE-dependent regulation of development. Plant Physiology 180, 937-951. Impact: journal issued a news and views commentary on this article

H. Yin, M. Li, D. Li, S.-A. Khan, S.R. Hepworth, and S.-M. Wang (2019) Transcriptome analysis reveals regulatory framework for salt and osmotic tolerance in a succulent xerophyte. BMC Plant Biology 19, 88.

N. Woerlen, G. Allam, A. Popescu, L. Corrigan, V. Pautot, and S.R. Hepworth. (2017) Repression of BLADE-ON-PETIOLE genes by KNOX homeodomain protein BREVIPEDICELLUS is essential for differentiation of secondary xylem in Arabidopsis roots. Planta 245,1079-1090.

S.R. Hepworth* and V. Pautot*. (2015) Beyond the divide: Boundaries for patterning and stem cell regulation in plants. Frontiers in Plant Science 6,1052. *co-corresponding authors. Impact: top 86% based on views, journal metrics report 

M. Khan, L. Ragni, P. Tabb, B.C. Salasini, S. Chatfield, R. Datla, J. Lock, X. Kuai, C. Després, M. Proveniers, C. Yongguo, D. Xiang, H. Morin, J.P. Rullière, S. Citerne, S.R. Hepworth*, and V. Pautot*. (2015) Repression of lateral organ boundary genes by PENNYWISE and POUND-FOOLISH is essential for meristem maintenance and flowering in Arabidopsis. Plant Physiology 169, 2166-2186. *co-corresponding authors.

M. Khan, H. Xu, and S.R. Hepworth. (2014) BLADE-ON-PETIOLE genes: Setting boundaries in development and defence. Plant Science 215-216, 157-171. Impact: this paper was an invited review.

M. Khan, P. Tabb, and S.R. Hepworth. (2012) BLADE-ON-PETIOLE1 and 2 regulate Arabidopsis inflorescence architecture in conjunction with homeobox genes KNAT6 and ATH1. Plant Signaling & Behavior 7, 1-5. Impact: this paper was an invited addendum.

M. Khan, M. Xu, J. Murmu, P. Tabb, Y. Liu, K. Storey, S.M. McKim, C.J. Douglas, and S.R. Hepworth. (2012) Antagonistic interaction of BLADE-ON-PETIOLE1 and 2 with BREVIPEDICELLUS and PENNYWISE regulates Arabidopsis inflorescence architecture. Plant Physiology 158, 946-960.

J. Murmu, M.J. Bush, C. DeLong, S. Li, M. Xu, M. Khan, C. Malcolmson, P.R. Fobert, S. Zachgo, and S.R. Hepworth. (2010) Arabidopsis bZIP transcription factors TGA9 and TGA10 interact with floral glutaredoxins ROXY1 and ROXY2 and are redundantly required for anther development. Plant Physiology 154, 1492-1504.

M. Xu, T. Hu, S. McKim, J. Murmu, G.W. Haughn, and S.R. Hepworth. (2010) Arabidopsis BLADE-ON-PETIOLE1 and 2 promote floral meristem fate and determinacy in a previously undefined pathway targeting APETALA1 and AGAMOUS-LIKE24. Plant Journal 63, 974-989. Impact: this paper was selected for an F1000 review.

S.M. McKim, G.-E. Stenvik, M.A. Butenko, W. Kristiansen, S.K. Cho, S.R. Hepworth, R.B. Aalen, and G.W. Haughn. (2008) The BLADE-ON-PETIOLE genes are essential for abscission zone formation in Arabidopsis. Development 135, 1537-1546. Impact: this paper was a cover image.

R. Kumar, K. Kushalappa, D. Godt, M.S. Pidkowich, S. Pastorelli, S.R. Hepworth, and G.W. Haughn. (2007) The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act redundantly to regulate KNOX expression spatially in leaf margins. Plant Cell 19, 2719-2735.

O. Rowland, H. Zheng, S.R. Hepworth, P. Lam, R. Jetter, and L. Kunst. (2006) CER4 encodes an alcohol-forming fatty acyl-coenzyme A reductase involved in cuticular wax production in Arabidopsis. Plant Physiology 142, 866-877.

S.R. Hepworth, J. Klenz, and G.W. Haughn. (2006) UFO in the Arabidopsis inflorescence apex is required for floral meristem identity and bract suppression. Planta 223, 769-778.

S.R. Hepworth, Y. Zhang, X. Li, S. McKim, and G.W. Haughn. (2005) BLADE-ON-PETIOLE-dependent signaling controls leaf and floral patterning in Arabidopsis. Plant Cell 17, 1-15.

H. An, C. Roussot, P. Suárez-López, L. Corbesier, C. Vincent, M. Piñeiro, S. Hepworth, A. Mouradov, S. Justin, C. Turnbull, and G. Coupland. (2004) CONSTANS acts in the phloem to regulate a systemic signal that induces photoperiodic flowering of Arabidopsis. Development 131, 3615-3626.

S.R. Hepworth, F. Valverde, D. Ravenscroft GS , A. Mouradov, and G. Coupland. (2002) Antagonistic regulation of flowering-time gene SOC1 by CONSTANS and FLC via separate promoter motifs. EMBO Journal 21, 4327-4337.

F. Robson, M.M. Costa, S.R. Hepworth, I. Vizir, M. Piñeiro, P.H. Reeves, J. Putterill, and G. Coupland. (2001) Functional importance of conserved domains in the flowering-time gene CONSTANS demonstrated by analysis of mutant alleles and transgenic plants. Plant Journal 28, 619-631.

S.R. Hepworth, H. Friesen, and J. Segall. (1998) NDT80 and the meiotic recombination checkpoint regulate expression of middle sporulation-specific genes in Saccharomyces cerevisiae. Molecular and Cellular Biology 18, 5750-5761.  Impact: reprinted in book as a "landmark paper" in yeast genetics 

H. Friesen, S.R. Hepworth, and J. Segall. (1997) An Ssn6-Tup1-dependent negative regulatory element controls sporulation-specific expression of DIT1 and DIT2 in Saccharomyces cerevisiae. Molecular and Cellular Biology 17, 123-134.

S.R. Hepworth, L.K. Ebusuzaki, and J. Segall. (1995) A 15-base-pair element activates the SPS4 gene midway through sporulation in Saccharomyces cerevisiae. Molecular and Cellular Biology 15, 3934-3944.

Z.E. Suntres, S.R. Hepworth, and P.N. Shek. (1993) Pulmonary uptake of liposome-associated α-tocopherol following intratracheal instillation in rats. Journal of Pharmacy and Pharmacology 45, 514-520.

Z.E. Suntres, S.R. Hepworth, and P.N. Shek. (1992) Protective effect of liposome-associated α-tocopherol against paraquat-induced acute lung toxicity. Biochemical Pharmacology 44,1811-1818.